Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi

Vitamin B2, also known as riboflavin, is essential for maintaining human health. The purpose of this study was to isolate novel lactic acid bacteria that overproduce vitamin B2 and validate their potential probiotics. In study, Lactobacillus plantarum HY7715 (HY7715) selected among isolated from Kimchi. showed a very high riboflavin-producing ability compared the control strain due expression ribA, ribB, ribC, ribH, ribG genes. produced 34.5 ± 2.41 mg/L riboflavin 24 h without consuming in medium under optimal growth conditions. It able produce an vitro model intestinal environment. addition, when deficiency induced mice through nutritional restriction, higher levels were detected plasma urine administration group than group. survival rate simulated gastrointestinal conditions had antibiotic resistance below cutoff MIC value suggested by European Food Safety Authority; moreover, it did not cause hemolysis. conclusion, could be considered beneficial probiotic animal applications, suggesting new alternative address deficiency.